GPRC5D-AS1

Across TCGA pan-cancer cohorts, GPRC5D-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GPRC5D-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GPRC5D-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPRC5D-AS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

COAD, LIHC, and THCA are the cancer types where GPRC5D-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPRC5D-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.534	<.001	10	view →
LIHC	Female	II,III,IV	+0.873	<.001	9	view →
THCA	All	All	−0.595	<.001	7	view →
KIRC	All	All	−0.534	<.001	7	view →
CHOL	Male	All	+2.083	<.001	5	view →
BLCA	All	All	+0.617	.013	5	view →
STAD	All	All	+0.416	.003	5	view →
LUAD	All	All	−0.290	.010	4	view →
BRCA	All	IV	+0.569	.009	2	view →
READ	All	All	+0.529	.006	2	view →
LUSC	All	All	+0.382	.002	2	view →
HNSC	All	All	+0.371	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GPRC5D-AS1–COAD

Open the COAD breakdown →