GPRC5C

Across TCGA pan-cancer cohorts, GPRC5C mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GPRC5C data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GPRC5C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPRC5C expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

PDAC, COAD, and HNSC are the cancer types where GPRC5C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.619	0.868	<.001	68	view →
COAD	DFS	Median	III,IV	0.698	1.000	.031	12	view →
HNSC	OS	Tertile	IV	0.558	0.925	.007	11	view →
LSCC	OS	Median	All	0.674	0.896	.004	11	view →
UCEC	DFS	Median	All	1.000	0.936	.022	2	view →
CCRCC	OS	Median	All	1.000	0.764	.047	1	view →
GBM	DFS	Median	All	0.836	0.545	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GPRC5C–PDAC (DFS)

Open the PDAC breakdown →