GPR87

Across TCGA patient cohorts, GPR87 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR87-associated genes across cancer lineages are EGFR_pY1068, cIAP, and eIF4E. Each is linked with GPR87 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR87-to-partner and partner-to-GPR87 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GPR87-low versus GPR87-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR87→partner) and Y-score (partner→GPR87) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.238	-1.415	.011	.046	3	2
UCEC	cIAP →	+0.104	+2.209	.044	.032	3	2
UCEC	eIF4E →	+0.235	+3.807	.003	<.001	2	2
SKCM	ACC1 →	+0.397	+3.000	.025	.036	3	1
SKCM	GSK3-a-b →	+0.197	+3.000	.027	.036	3	1
SKCM	YAP →	+0.235	+3.000	.038	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

EGFR_pY1068 by GPR87 expression — UCEC

Explore this box plot interactively →