GPR87

Across TCGA pan-cancer cohorts, GPR87 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GPR87 data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GPR87 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GPR87 expression acts as an unfavorable survival marker, although some lineages such as SCLC and LUSC show a favorable association.

KIRC, HNSC, and PAAD are the cancer types where GPR87 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.522	0.720	<.001	135	view →
HNSC	OS	Median	IV	0.352	0.667	.001	90	view →
PAAD	OS	Tertile	All	0.372	0.690	<.001	79	view →
STAD	DFS	Tertile	All	0.440	0.659	<.001	75	view →
SKCM	OS	Tertile	All	0.670	0.824	<.001	46	view →
DLBC	DFS	Quartile	II,III,IV	0.380	0.951	.006	39	view →
UVM	DFS	Tertile	All	0.324	0.626	.035	36	view →
READ	DFS	Tertile	IV	0.271	0.774	<.001	35	view →
UCEC	DFS	Median	All	0.583	0.697	.004	24	view →
LGG	DFS	Median	All	0.297	0.459	.001	23	view →
PCPG	DFS	Tertile	All	0.571	0.898	<.001	19	view →
TGCT	DFS	Tertile	All	0.716	0.956	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GPR87–KIRC (OS)

Open the KIRC breakdown →