GPR83

Across TCGA pan-cancer cohorts, GPR83 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GPR83 data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher GPR83 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GPR83 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, ESCA, and SCLC are the cancer types where GPR83 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.604	0.967	<.001	39	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	12	view →
SCLC	OS	Median	All	0.205	0.713	<.001	12	view →
LIHC	DFS	Median	All	0.109	0.545	<.001	12	view →
PRAD	OS	Median	All	0.491	0.893	<.001	8	view →
UCEC	DFS	Median	II,III,IV	1.000	0.443	.034	8	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GPR83–THYM (OS)

Open the THYM breakdown →