GPR83

Across TCGA pan-cancer cohorts, GPR83 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GPR83 data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GPR83 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GPR83 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LUAD, PDAC, and LSCC are the cancer types where GPR83 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.843	1.000	.003	13	view →
PDAC	OS	Tertile	III,IV	0.993	0.734	.024	10	view →
LSCC	DFS	Tertile	All	0.354	0.853	.012	10	view →
GBM	OS	Tertile	All	0.794	0.887	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GPR83–LUAD (OS)

Open the LUAD breakdown →