GPR75-ASB3

Across TCGA cell cohorts, GPR75-ASB3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GPR75-ASB3-associated genes across cancer lineages are C8A, FFAR3, and CEACAM4. Each is linked with GPR75-ASB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR75-ASB3-to-partner and partner-to-GPR75-ASB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C8A grouped by GPR75-ASB3-low versus GPR75-ASB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR75-ASB3→partner) and Y-score (partner→GPR75-ASB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C8A →	+0.031	+3.684	<.001	.006	3	1
LUNG_SCLC	FFAR3 →	+0.055	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	CEACAM4 →	+0.075	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	LGALS16 →	+0.067	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

C8A by GPR75-ASB3 expression — LARGE_INTESTINE

Explore this box plot interactively →