GPR61

Across TCGA patient cohorts, GPR61 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR61-associated genes across cancer lineages are eEF2, A-Raf_pS299, and MEK1. Each is linked with GPR61 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR61-to-partner and partner-to-GPR61 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GPR61-low versus GPR61-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR61→partner) and Y-score (partner→GPR61) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.372	+2.000	.005	.029	3	2
UCEC	A-Raf_pS299 →	-0.179	-2.662	<.001	<.001	3	2
UCEC	MEK1 →	+0.322	+1.415	.019	.046	3	2
UCEC	MSH2 →	-0.247	-2.449	.004	.019	3	2
UCEC	N-Ras →	-0.103	-2.156	.021	.003	3	2
UCEC	Shc_pY317 →	-0.195	-2.169	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eEF2 by GPR61 expression — UCEC

Explore this box plot interactively →