GPR61

Across TCGA pan-cancer cohorts, GPR61 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GPR61’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GPR61 RNA is repressed in tumor relative to normal tissue. In most cancer types GPR61 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and LIHC are the cancer types where GPR61 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR61 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.257	<.001	8	view →
KIRC	Male	III,IV	−0.089	.002	7	view →
LIHC	All	All	+0.054	<.001	6	view →
LUSC	All	All	+0.077	<.001	4	view →
BLCA	All	All	+0.307	.008	3	view →
LUAD	Male	All	+0.103	.006	2	view →
THCA	Male	II,III,IV	−0.393	.042	1	view →
CHOL	Male	All	+0.034	.047	1	view →
HNSC	All	III,IV	+0.025	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

GPR61–KICH

Open the KICH breakdown →