GPR61

Across TCGA cell cohorts, GPR61 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,353 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR61-associated GO terms across cancer lineages are Regulation of RNA splicing, Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway, and Positive regulation of protein autoubiquitination. Each is linked with GPR61 in more than 7 cancer types. Because this analysis shows association rather than direction, both GPR61-to-partner and partner-to-GPR61 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by GPR61-low versus GPR61-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR61→partner) and Y-score (partner→GPR61) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of RNA splicing →	+0.094	+0.392	<.001	<.001	3	8
OVARY	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.096	+0.351	.001	.002	3	8
OESOPHAGUS	Positive regulation of protein autoubiquitination →	+0.114	+0.326	<.001	.003	3	7
UPPER_AERODIGESTIVE_TRACT	Nucleic acid catabolic process →	+0.044	+0.313	.006	.005	3	7
OVARY	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.086	+0.269	<.001	<.001	3	7
OVARY	Spliceosomal complex assembly →	+0.093	+0.408	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,353 associations by consensus.

Regulation of RNA splicing by GPR61 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →