GPR61

Across TCGA cell cohorts, GPR61 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR61-associated genes across cancer lineages are ECE2, COX6A2, and TBC1D21. Each is linked with GPR61 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR61-to-partner and partner-to-GPR61 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECE2 grouped by GPR61-low versus GPR61-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR61→partner) and Y-score (partner→GPR61) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ECE2 →	+0.332	+4.054	<.001	.004	3	1
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	CCER1 →	+0.013	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	SPINK9 →	+0.351	+3.793	<.001	.007	3	1
LARGE_INTESTINE	IQCF6 →	+0.277	+4.882	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ECE2 by GPR61 expression — LARGE_INTESTINE

Explore this box plot interactively →