GPR6

Across TCGA patient cohorts, GPR6 mutation is significantly associated with the RNA expression of many other genes, with 1,463 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR6-associated genes across cancer lineages are ITGAE, CDCA2, and TRAJ31. Each is linked with GPR6 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR6-to-partner and partner-to-GPR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAE grouped by GPR6-low versus GPR6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR6→partner) and Y-score (partner→GPR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ITGAE →	+0.500	+2.459	<.001	<.001	3	3
UCEC	CDCA2 →	+0.874	+3.021	<.001	<.001	3	3
UCEC	TRAJ31 →	+0.462	+1.650	.006	.003	3	3
STAD	NPM3 →	+0.927	+3.219	.001	.009	3	3
STAD	ECHS1 →	+0.571	+3.203	.003	.009	3	3
STAD	C4BPAP1 →	+0.361	+4.269	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,463 associations by consensus.

ITGAE by GPR6 expression — UCEC

Explore this box plot interactively →