GPR55

Across TCGA patient cohorts, GPR55 mutation is significantly associated with the RNA expression of many other genes, with 430 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR55-associated genes across cancer lineages are SCGB1D1, MTMR10, and OR8D4. Each is linked with GPR55 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR55-to-partner and partner-to-GPR55 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1D1 grouped by GPR55-low versus GPR55-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR55→partner) and Y-score (partner→GPR55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	SCGB1D1 →	+0.130	+5.653	<.001	.003	3	2
UCEC	MTMR10 →	+0.516	+3.370	<.001	.005	3	2
LUSC	OR8D4 →	+0.163	+4.059	<.001	.002	3	2
UCEC	RNA5SP146 →	+0.351	+2.261	<.001	.007	3	2
UCEC	RNA5SP436 →	+0.400	+3.237	<.001	.001	3	2
UCEC	UFSP2 →	+0.517	+2.265	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 430 associations by consensus.

SCGB1D1 by GPR55 expression — READ

Explore this box plot interactively →