GPR50

Across TCGA pan-cancer cohorts, GPR50 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GPR50 data layer compared with 23 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GPR50 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated GPR50 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, COAD, and ESCA are the cancer types where GPR50 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.863	.016	18	view →
COAD	OS	Median	IV	0.089	0.649	.005	15	view →
ESCA	OS	Median	All	0.080	0.701	<.001	12	view →
SCLC	DFS	Median	All	0.247	0.635	.013	9	view →
SKCM	DFS	Median	All	0.965	0.608	.003	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GPR50–UCEC (OS)

Open the UCEC breakdown →