GPR50

Across TCGA patient cohorts, GPR50 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,421 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible GPR50-associated GO terms across cancer lineages are Regulation of transcription by RNA polymerase I, Maintenance of cell number, and Morphogenesis of a polarized epithelium. Each is linked with GPR50 in more than 15 cancer types. Because this analysis shows association rather than direction, both GPR50-to-partner and partner-to-GPR50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription by RNA polymerase I grouped by GPR50-low versus GPR50-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR50→partner) and Y-score (partner→GPR50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of transcription by RNA polymerase I →	+0.071	+0.162	<.001	.004	2	16
TGCT	Maintenance of cell number →	+0.044	+1.172	<.001	<.001	3	13
STAD	Morphogenesis of a polarized epithelium →	+0.051	+0.224	<.001	<.001	3	13
TGCT	Positive regulation of Wnt signaling pathway →	+0.037	+1.000	<.001	.001	3	13
MESO	Regulation of muscle cell differentiation →	+0.028	+0.191	<.001	.005	2	14
STAD	Positive regulation of mitotic cell cycle phase transition →	+0.039	+0.145	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,421 associations by consensus.

Regulation of transcription by RNA polymerase I by GPR50 expression — STAD

Explore this box plot interactively →