GPR45

Across TCGA patient cohorts, GPR45 mutation is significantly associated with the RNA expression of many other genes, with 2,264 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR45-associated genes across cancer lineages are TXNL1, FCER1A, and PRC1. Each is linked with GPR45 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR45-to-partner and partner-to-GPR45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNL1 grouped by GPR45-low versus GPR45-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR45→partner) and Y-score (partner→GPR45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TXNL1 →	+0.581	+3.223	<.001	.009	3	3
UCEC	FCER1A →	-1.029	-4.392	<.001	<.001	3	3
UCEC	PRC1 →	+0.710	+2.169	.001	.003	3	3
UCEC	NAE1 →	+0.572	+2.917	<.001	<.001	3	3
UCEC	ORC1 →	+0.793	+2.169	<.001	.003	3	3
UCEC	WDR76 →	+0.703	+2.753	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,264 associations by consensus.

TXNL1 by GPR45 expression — COAD

Explore this box plot interactively →