GPR45

Across TCGA patient cohorts, GPR45 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR45-associated genes across cancer lineages are p38-MAPK_pT180_Y182, STAT3_pY705, and Ku80. Each is linked with GPR45 in more than 3 cancer types. Because this analysis shows association rather than direction, both GPR45-to-partner and partner-to-GPR45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by GPR45-low versus GPR45-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR45→partner) and Y-score (partner→GPR45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.625	-2.700	<.001	.006	3	3
UCEC	STAT3_pY705 →	-0.405	-2.584	<.001	.010	3	2
UCEC	Ku80 →	+0.217	+1.498	.022	.036	3	2
UCEC	Notch1 →	+0.234	+1.887	<.001	.029	3	2
UCEC	PRDX1 →	+0.216	+2.584	.009	.010	3	2
UCEC	TIGAR →	+0.232	+2.441	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

p38-MAPK_pT180_Y182 by GPR45 expression — UCEC

Explore this box plot interactively →