GPR45

Across TCGA cell cohorts, GPR45 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,607 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible GPR45-associated GO terms across cancer lineages are Regulation of translational initiation, Regulation of DNA-templated transcription initiation, and Retrograde transport, endosome to Golgi. Each is linked with GPR45 in more than 8 cancer types. Because this analysis shows association rather than direction, both GPR45-to-partner and partner-to-GPR45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translational initiation grouped by GPR45-low versus GPR45-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR45→partner) and Y-score (partner→GPR45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of translational initiation →	+0.051	+0.068	.001	.004	2	9
OESOPHAGUS	Regulation of DNA-templated transcription initiation →	+0.084	+0.176	.001	.001	3	8
SKIN	Retrograde transport, endosome to Golgi →	+0.074	+0.264	<.001	.002	3	8
OESOPHAGUS	Establishment of protein localization to organelle →	+0.046	+0.138	.003	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Vesicle-mediated transport to the plasma membrane →	+0.079	+0.084	<.001	<.001	3	7
OESOPHAGUS	Negative regulation of autophagy →	+0.075	+0.173	.003	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,607 associations by consensus.

Regulation of translational initiation by GPR45 expression — BLOOD_Lymphoma

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