GPR45

Across TCGA cell cohorts, GPR45 mutation is significantly associated with the mutation status of many other genes, with 3,646 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR45-associated genes across cancer lineages are PCDHB12, ARHGEF11, and THRAP3. Each is linked with GPR45 in more than 3 cancer types. Because this analysis shows association rather than direction, both GPR45-to-partner and partner-to-GPR45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDHB12 grouped by GPR45-low versus GPR45-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR45→partner) and Y-score (partner→GPR45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PCDHB12 →	+4.247	+4.554	.001	.001	1	4
BLOOD_Lymphoma	ARHGEF11 →	+3.247	+3.922	.004	.004	1	4
BLOOD_Lymphoma	THRAP3 →	+5.247	+4.429	.005	.005	1	4
OVARY	ABCC8 →	+4.345	+4.345	<.001	<.001	1	4
LARGE_INTESTINE	CHD8 →	+1.925	+2.643	<.001	<.001	1	4
LARGE_INTESTINE	TANC1 →	+1.925	+2.378	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,646 associations by consensus.

PCDHB12 by GPR45 expression — BLOOD_Lymphoma

Explore this box plot interactively →