GPR4

Across TCGA patient cohorts, GPR4 mutation is significantly associated with the RNA expression of many other genes, with 4,088 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR4-associated genes across cancer lineages are TFAMP1, GAGE2E, and OR4M1. Each is linked with GPR4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR4-to-partner and partner-to-GPR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFAMP1 grouped by GPR4-low versus GPR4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR4→partner) and Y-score (partner→GPR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TFAMP1 →	+0.179	+3.199	<.001	.005	3	3
LUAD	GAGE2E →	+0.096	+4.197	.002	.009	3	3
CESC	OR4M1 →	+0.014	+4.020	<.001	.009	3	2
CESC	MTND4LP20 →	+0.071	+4.842	<.001	.002	3	2
READ	RNU6-891P →	+0.675	+5.039	<.001	.008	3	2
UCEC	RNU6ATAC30P →	+0.338	+1.976	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,088 associations by consensus.

TFAMP1 by GPR4 expression — COAD

Explore this box plot interactively →