GPR37L1

Across TCGA patient cohorts, GPR37L1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR37L1-associated genes across cancer lineages are EGFR_pY1068, Di-Ras3, and TSC1. Each is linked with GPR37L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR37L1-to-partner and partner-to-GPR37L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GPR37L1-low versus GPR37L1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR37L1→partner) and Y-score (partner→GPR37L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EGFR_pY1068 →	-0.233	-2.982	.011	.036	3	2
UCEC	Di-Ras3 →	-0.166	-2.986	.016	.035	3	2
COAD	TSC1 →	-0.378	-2.991	.008	.036	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.430	+2.179	.030	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.238	-2.571	.002	.011	3	1
UCEC	MSH6 →	-0.474	-2.999	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by GPR37L1 expression — SKCM

Explore this box plot interactively →