GPR37L1

Across TCGA pan-cancer cohorts, GPR37L1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GPR37L1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GPR37L1 RNA is repressed in tumor relative to normal tissue. In most cancer types GPR37L1 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and KIRP are the cancer types where GPR37L1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR37L1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.061	<.001	10	view →
THCA	Male	All	−0.633	<.001	9	view →
KIRP	All	II,III,IV	+0.185	<.001	9	view →
LIHC	Male	II,III,IV	+0.307	<.001	8	view →
CHOL	Male	All	+0.431	<.001	5	view →
KIRC	Male	All	+0.107	<.001	5	view →
BRCA	All	II,III,IV	+0.348	<.001	4	view →
LUAD	All	All	+0.151	.004	4	view →
BLCA	Female	All	+0.406	.024	3	view →
LUSC	Male	All	+0.262	<.001	3	view →
HNSC	Male	All	+0.210	.014	3	view →
READ	All	All	−0.657	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GPR37L1–COAD

Open the COAD breakdown →