GPR31

Across TCGA patient cohorts, GPR31 mutation is significantly associated with the RNA expression of many other genes, with 623 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR31-associated genes across cancer lineages are RNU7-61P, MRPL42P2, and RPS5P7. Each is linked with GPR31 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR31-to-partner and partner-to-GPR31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-61P grouped by GPR31-low versus GPR31-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR31→partner) and Y-score (partner→GPR31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU7-61P →	+1.538	+4.009	<.001	.003	3	3
BLCA	MRPL42P2 →	+0.577	+3.891	<.001	.004	3	2
BLCA	RPS5P7 →	+0.096	+3.564	.001	.004	3	2
BLCA	SLC25A5P4 →	+0.048	+3.973	<.001	.003	3	2
BLCA	RNU6-677P →	+0.622	+3.989	<.001	.003	3	2
LUAD	RDM1P2 →	+0.122	+4.194	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 623 associations by consensus.

RNU7-61P by GPR31 expression — BLCA

Explore this box plot interactively →