GPR31

Across TCGA pan-cancer cohorts, GPR31 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GPR31’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GPR31 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPR31 is over-expressed in tumor, although a few such as UCEC and COAD show the opposite, repressed pattern.

KIRC, UCEC, and COAD are the cancer types where GPR31 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR31 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.267	<.001	12	view →
UCEC	All	All	−0.204	.002	6	view →
COAD	All	II,III,IV	−0.139	<.001	6	view →
BRCA	All	All	+0.170	<.001	4	view →
STAD	Female	All	+0.241	.047	2	view →
LUAD	All	IV	+0.240	.006	2	view →
THCA	All	All	−0.100	.016	2	view →
LUSC	Female	III,IV	+0.365	.039	1	view →
STAD	Male	IV	−0.215	.027	1	view →
KICH	All	III,IV	−0.057	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

GPR31–KIRC

Open the KIRC breakdown →