GPR31

Across TCGA patient cohorts, GPR31 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR31-associated genes across cancer lineages are EGFR, VHL, and Bak. Each is linked with GPR31 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR31-to-partner and partner-to-GPR31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by GPR31-low versus GPR31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR31→partner) and Y-score (partner→GPR31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.165	-3.000	.022	.036	3	1
UCEC	VHL →	-1.240	-3.584	<.001	.002	3	1
UCEC	Bak →	+0.252	+2.000	.025	.032	3	1
UCEC	c-Met_pY1235 →	+0.074	+2.179	.026	.034	3	1
UCEC	IGFBP2 →	-0.966	-3.169	<.001	.019	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

EGFR by GPR31 expression — UCEC

Explore this box plot interactively →