GPR3

Across TCGA patient cohorts, GPR3 mutation is significantly associated with the RNA expression of many other genes, with 1,786 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR3-associated genes across cancer lineages are RCE1, CAPZB, and SNRPGP17. Each is linked with GPR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR3-to-partner and partner-to-GPR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCE1 grouped by GPR3-low versus GPR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR3→partner) and Y-score (partner→GPR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCE1 →	+0.373	+3.491	.006	.002	3	2
UCEC	CAPZB →	+0.363	+2.617	<.001	<.001	3	2
COAD	SNRPGP17 →	+0.234	+3.598	<.001	<.001	3	2
CESC	LARP7P2 →	+0.262	+4.127	<.001	.003	3	2
UCEC	FCER1A →	-0.893	-4.321	<.001	<.001	3	2
UCEC	POLR2A →	+0.607	+3.491	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,786 associations by consensus.

RCE1 by GPR3 expression — UCEC

Explore this box plot interactively →