GPR27

Across TCGA patient cohorts, GPR27 mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible GPR27-associated genes across cancer lineages are OR5L2, TEX36-AS1, and MIR1976. Each is linked with GPR27 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR27-to-partner and partner-to-GPR27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5L2 grouped by GPR27-low versus GPR27-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR27→partner) and Y-score (partner→GPR27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR5L2 →	+0.034	+7.930	<.001	.008	3	2
HNSC	TEX36-AS1 →	+0.204	+5.368	<.001	.005	3	2
HNSC	MIR1976 →	+0.694	+6.763	<.001	<.001	3	2
LUAD	AARS1P1 →	+0.069	+7.930	<.001	.008	3	1
LUAD	MIR4695 →	+0.348	+7.930	<.001	.008	3	1
SKCM	SLC16A12-AS1 →	+0.049	+4.884	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

OR5L2 by GPR27 expression — LUAD

Explore this box plot interactively →