GPR27

Across TCGA pan-cancer cohorts, GPR27 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated GPR27 data layer compared with 4 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher GPR27 RNA is associated with better overall survival. In most high-consensus cancer types, elevated GPR27 expression acts as an unfavorable survival marker, although some lineages such as BRCA and OV show a favorable association.

BRCA, OV, and UVM are the cancer types where GPR27 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.945	0.901	.001	121	view →
OV	OS	Median	All	0.754	0.627	<.001	108	view →
UVM	OS	Median	II,III,IV	0.826	0.449	<.001	97	view →
STAD	DFS	Median	II,III,IV	0.523	0.696	.003	55	view →
LGG	OS	Median	All	0.526	0.355	<.001	49	view →
ACC	OS	Median	III,IV	0.714	0.161	<.001	35	view →
KIRC	DFS	Median	IV	0.720	0.503	.002	34	view →
SKCM	OS	Tertile	IV	0.730	0.244	.010	29	view →
HNSC	DFS	Tertile	All	0.225	0.389	.008	28	view →
PAAD	DFS	Median	All	0.466	0.265	.007	27	view →
LUSC	DFS	Median	III,IV	0.313	0.678	<.001	26	view →
THYM	DFS	Tertile	All	1.000	0.646	.009	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GPR27–BRCA (OS)

Open the BRCA breakdown →