GPR27

Across TCGA cell cohorts, GPR27 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GPR27-associated genes across cancer lineages are TCP10L2, OR4F4, and LORICRIN. Each is linked with GPR27 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR27-to-partner and partner-to-GPR27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCP10L2 grouped by GPR27-low versus GPR27-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR27→partner) and Y-score (partner→GPR27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TCP10L2 →	+0.064	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR4F4 →	+0.012	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	LORICRIN →	+0.019	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRAMEF18 →	+0.006	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TCP10L2 by GPR27 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →