GPR26

Across TCGA patient cohorts, GPR26 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. COAD shows the largest number of these associations.

The most reproducible GPR26-associated genes across cancer lineages are Cyclin-B1, Ku80, and MIG-6. Each is linked with GPR26 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR26-to-partner and partner-to-GPR26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by GPR26-low versus GPR26-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR26→partner) and Y-score (partner→GPR26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-B1 →	+0.642	+2.815	.031	.036	3	3
UCEC	Ku80 →	+0.224	+2.598	.042	.006	3	1
COAD	MIG-6 →	+0.116	+2.866	.032	.033	3	1
UCEC	Tuberin →	+0.348	+2.817	.005	.036	2	1
UCEC	Caspase-8 →	-0.314	-3.700	.007	.001	2	1
COAD	Caspase-7-cleavedD198 →	+1.344	+2.815	.001	.036	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Cyclin-B1 by GPR26 expression — COAD

Explore this box plot interactively →