GPR26

Across TCGA pan-cancer cohorts, GPR26 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GPR26’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where GPR26 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPR26 is over-expressed in tumor, although a few such as READ and COAD show the opposite, repressed pattern.

BRCA, KICH, and READ are the cancer types where GPR26 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR26 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	+0.328	.001	8	view →
KICH	Female	All	+0.080	<.001	7	view →
READ	All	All	−0.112	.006	4	view →
COAD	All	All	−0.050	.006	4	view →
STAD	All	All	−0.109	.007	3	view →
BLCA	All	IV	−0.137	.006	2	view →
UCEC	All	III,IV	−0.056	.022	2	view →
LUSC	All	All	+0.035	.049	1	view →
LUSC	Male	III,IV	−0.027	.037	1	view →
THCA	All	All	−0.006	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

GPR26–BRCA

Open the BRCA breakdown →