GPR26

Across TCGA cell cohorts, GPR26 RNA expression is significantly associated with the go_rna of many other GO terms, with 276 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GPR26-associated GO terms across cancer lineages are Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, Cytoskeleton-dependent intracellular transport, and Regulation of proteasomal ubiquitin-dependent protein catabolic process. Each is linked with GPR26 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR26-to-partner and partner-to-GPR26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway grouped by GPR26-low versus GPR26-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR26→partner) and Y-score (partner→GPR26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway →	+0.103	+1.039	<.001	.005	3	2
LUNG_SCLC	Cytoskeleton-dependent intracellular transport →	+0.058	+0.881	<.001	.008	3	2
LUNG_SCLC	Regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.056	+0.995	<.001	.008	3	2
LUNG_SCLC	Wound healing, spreading of epidermal cells →	-0.249	-1.039	<.001	.004	3	2
LUNG_SCLC	Synaptic vesicle recycling →	+0.096	+1.273	.002	.002	3	2
LUNG_SCLC	Regulation of glutamate uptake involved in transmission of nerve impulse →	-0.158	-0.785	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 276 associations by consensus.

Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway by GPR26 expression — LUNG_SCLC

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