GPR26

Across TCGA cell cohorts, GPR26 mutation is significantly associated with the RNA expression of many other genes, with 173 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR26-associated genes across cancer lineages are TOPAZ1, ARGFX, and CBY1. Each is linked with GPR26 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR26-to-partner and partner-to-GPR26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOPAZ1 grouped by GPR26-low versus GPR26-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR26→partner) and Y-score (partner→GPR26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TOPAZ1 →	+0.009	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	ARGFX →	+0.024	+4.662	<.001	.005	3	1
LARGE_INTESTINE	CBY1 →	+0.613	+3.160	.002	.006	3	1
LARGE_INTESTINE	VAPA →	+0.529	+3.212	.007	.006	3	1
LARGE_INTESTINE	FZD3 →	+0.900	+3.212	<.001	.006	3	1
LARGE_INTESTINE	FGF8 →	+0.341	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 173 associations by consensus.

TOPAZ1 by GPR26 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →