GPR22

Across TCGA cell cohorts, GPR22 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GPR22-associated genes across cancer lineages are GSTA3, VWC2, and OR4A47. Each is linked with GPR22 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR22-to-partner and partner-to-GPR22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSTA3 grouped by GPR22-low versus GPR22-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR22→partner) and Y-score (partner→GPR22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSTA3 →	+0.088	+3.684	.005	.006	3	1
LARGE_INTESTINE	VWC2 →	+0.132	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR4A47 →	+0.018	+4.437	<.001	.004	3	1
BLOOD_Lymphoma	OR9A2 →	+0.022	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	VN1R2 →	+0.006	+5.643	.003	.002	3	1
BLOOD_Lymphoma	OR14A16 →	+0.023	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GSTA3 by GPR22 expression — LARGE_INTESTINE

Explore this box plot interactively →