Across TCGA patient cohorts, GPR20 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR20-associated genes across cancer lineages are Akt_pS473, 14-3-3_beta, and eIF4E. Each is linked with GPR20 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR20-to-partner and partner-to-GPR20 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR20→partner) and Y-score (partner→GPR20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pS473 →	+0.691	+2.999	.032	.035	3	2
UCEC	14-3-3_beta →	-0.130	-2.295	.004	.033	3	1
UCEC	eIF4E →	+0.213	+2.700	.025	.006	2	2
UCEC	ERK2 →	+0.219	+2.000	.011	.032	3	1
UCEC	Fibronectin →	-0.339	-2.575	.022	.010	3	1
UCEC	ACC_pS79 →	+0.333	+2.000	.033	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

GPR20 survival (RNA) · tumor vs normal (RNA) · all GPR20 data types