GPR180

Across TCGA cell cohorts, GPR180 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible GPR180-associated genes across cancer lineages are OR4E2, SERPINA12, and OPRPN. Each is linked with GPR180 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR180-to-partner and partner-to-GPR180 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4E2 grouped by GPR180-low versus GPR180-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR180→partner) and Y-score (partner→GPR180) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR4E2 →	+0.025	+5.169	<.001	.005	3	2
PANCREAS	SERPINA12 →	+0.016	+5.614	<.001	.002	3	1
PANCREAS	OPRPN →	+0.029	+5.000	<.001	.006	3	1
PANCREAS	USP17L3 →	+0.016	+5.000	<.001	.006	3	1
PANCREAS	RGS21 →	+0.006	+5.614	<.001	.002	3	1
LARGE_INTESTINE	SAXO1 →	+0.042	+3.556	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR4E2 by GPR180 expression — BREAST

Explore this box plot interactively →