GPR179

Across TCGA patient cohorts, GPR179 mutation is significantly associated with the RNA expression of many other genes, with 6,546 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR179-associated genes across cancer lineages are ZBTB8OS, PTMAP2, and PTMAP5. Each is linked with GPR179 in more than 4 cancer types. Because this analysis shows association rather than direction, both GPR179-to-partner and partner-to-GPR179 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZBTB8OS grouped by GPR179-low versus GPR179-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR179→partner) and Y-score (partner→GPR179) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZBTB8OS →	+0.339	+1.617	<.001	<.001	3	5
STAD	PTMAP2 →	+0.930	+3.459	<.001	.004	3	4
STAD	PTMAP5 →	+0.981	+3.597	<.001	.001	3	4
COAD	CHCHD4 →	+0.281	+2.542	.009	.001	3	4
UCEC	ZFYVE19 →	+0.325	+1.233	<.001	<.001	3	4
UCEC	SAAL1 →	+0.437	+2.069	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,546 associations by consensus.

ZBTB8OS by GPR179 expression — UCEC

Explore this box plot interactively →