GPR179

Across TCGA patient cohorts, GPR179 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR179-associated genes across cancer lineages are INPP4B, Notch1, and AMPK_alpha. Each is linked with GPR179 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR179-to-partner and partner-to-GPR179 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by GPR179-low versus GPR179-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR179→partner) and Y-score (partner→GPR179) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.330	-1.874	.017	.047	3	3
UCEC	Notch1 →	+0.135	+1.442	<.001	.002	3	3
BLCA	AMPK_alpha →	+0.130	+3.017	.040	.017	3	2
STAD	Src_pY527 →	-0.668	-3.169	.001	.018	3	2
UCEC	STAT3_pY705 →	-0.282	-1.432	<.001	.003	3	2
SKCM	4E-BP1_pS65 →	+0.147	+1.690	.018	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

INPP4B by GPR179 expression — COAD

Explore this box plot interactively →