GPR179

Across TCGA cell cohorts, GPR179 mutation is significantly associated with the RNA expression of many other genes, with 1,889 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR179-associated genes across cancer lineages are PPP2R5E, CYB5R4, and RPL5. Each is linked with GPR179 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR179-to-partner and partner-to-GPR179 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2R5E grouped by GPR179-low versus GPR179-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR179→partner) and Y-score (partner→GPR179) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP2R5E →	+0.519	+3.629	<.001	<.001	3	3
SKIN	CYB5R4 →	+0.581	+3.364	.005	.002	3	3
LARGE_INTESTINE	RPL5 →	+0.431	+2.043	.002	.001	3	3
LARGE_INTESTINE	CD63 →	-0.568	-2.459	<.001	<.001	3	3
BLOOD_Leukemia	TIFA →	+1.073	+2.730	.002	.001	3	3
LARGE_INTESTINE	RPL9 →	+0.522	+2.129	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,889 associations by consensus.

PPP2R5E by GPR179 expression — LARGE_INTESTINE

Explore this box plot interactively →