GPR176

Across TCGA pan-cancer cohorts, GPR176 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated GPR176 data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher GPR176 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPR176 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LUSC and SKCM are the cancer types where GPR176 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	II,III,IV	0.156	0.720	<.001	24	view →
SKCM	DFS	Median	II,III,IV	0.850	0.680	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

GPR176–LUSC (DFS)

Open the LUSC breakdown →