GPR176

Across TCGA patient cohorts, GPR176 protein abundance is significantly associated with the RNA expression of many other genes, with 87 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible GPR176-associated genes across cancer lineages are SLC7A6, PPP1R13L, and GSDME. Each is linked with GPR176 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR176-to-partner and partner-to-GPR176 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPR176 versus SLC7A6 in HNSC, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR176→partner) and Y-score (partner→GPR176) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC7A6 →	+0.699	+0.353	.009	.008	3	1
HNSC	PPP1R13L →	+0.890	+0.620	.002	.005	3	1
HNSC	GSDME →	+1.536	+0.620	.001	.005	3	1
HNSC	PIK3R3 →	-0.971	-0.620	.001	.005	3	1
HNSC	RAB22A →	+0.729	+0.620	.001	.005	3	1
HNSC	ATG12 →	+0.722	+0.437	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

GPR176 vs SLC7A6 — HNSC

Explore this scatter interactively →