GPR176

Across TCGA patient cohorts, GPR176 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR176-associated genes across cancer lineages are ACC1, N-Ras, and CDK1. Each is linked with GPR176 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR176-to-partner and partner-to-GPR176 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by GPR176-low versus GPR176-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR176→partner) and Y-score (partner→GPR176) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.364	+3.000	.038	.036	3	2
UCEC	N-Ras →	-0.138	-2.973	.016	.035	3	2
UCEC	CDK1 →	+0.145	+2.820	.046	.035	3	2
UCEC	14-3-3_beta →	-0.135	-2.301	.005	.034	3	1
UCEC	MSH2 →	-0.343	-2.973	.002	.035	3	1
UCEC	p21 →	+0.287	+2.459	.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ACC1 by GPR176 expression — UCEC

Explore this box plot interactively →