GPR176

Across TCGA cell cohorts, GPR176 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GPR176-associated genes across cancer lineages are WDR87, REG3G, and BSX. Each is linked with GPR176 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR176-to-partner and partner-to-GPR176 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR87 grouped by GPR176-low versus GPR176-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR176→partner) and Y-score (partner→GPR176) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WDR87 →	+0.021	+3.453	<.001	.009	3	2
BLOOD_Lymphoma	REG3G →	+0.044	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	BSX →	+0.183	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	IFNL3 →	+0.142	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.207	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP9-2 →	+0.043	+6.247	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

WDR87 by GPR176 expression — LARGE_INTESTINE

Explore this box plot interactively →