GPR176

Across TCGA cell cohorts, GPR176 mutation is significantly associated with the mutation status of many other genes, with 2,714 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR176-associated genes across cancer lineages are SYNRG, ERBB4, and GIGYF2. Each is linked with GPR176 in more than 3 cancer types. Because this analysis shows association rather than direction, both GPR176-to-partner and partner-to-GPR176 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYNRG grouped by GPR176-low versus GPR176-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR176→partner) and Y-score (partner→GPR176) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SYNRG →	+4.772	+5.339	.004	.004	1	4
BLOOD_Leukemia	ERBB4 →	+2.779	+4.326	.006	.006	1	4
UPPER_AERODIGESTIVE_TRACT	GIGYF2 →	+5.392	+5.392	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	KLC2 →	+4.392	+4.954	.008	.008	1	4
LARGE_INTESTINE	PHF3 →	+1.974	+3.801	.004	.004	1	4
LUNG_NSCLC_LUAD	TNKS1BP1 →	+4.772	+5.339	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,714 associations by consensus.

SYNRG by GPR176 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →