GPR176-DT

Across TCGA pan-cancer cohorts, GPR176-DT RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GPR176-DT data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GPR176-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPR176-DT expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

HNSC, BRCA, and DLBC are the cancer types where GPR176-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.547	0.704	<.001	91	view →
BRCA	OS	Tertile	II,III,IV	0.877	0.933	.004	52	view →
DLBC	DFS	Median	II,III,IV	0.563	0.980	<.001	46	view →
ACC	DFS	Median	II,III,IV	0.477	0.715	.003	44	view →
KICH	DFS	Tertile	All	0.509	1.000	<.001	41	view →
BLCA	DFS	Tertile	II,III,IV	0.239	0.395	.004	38	view →
COAD	DFS	Quartile	All	0.426	0.580	.011	30	view →
KIRC	DFS	Tertile	III,IV	0.599	0.806	.005	28	view →
THCA	OS	Tertile	II,III,IV	0.656	0.844	.008	24	view →
UCS	DFS	Tertile	II,III,IV	0.627	0.171	.005	18	view →
UVM	DFS	Median	III,IV	0.489	0.773	.023	16	view →
OV	OS	Median	III,IV	0.807	0.859	.013	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GPR176-DT–HNSC (DFS)

Open the HNSC breakdown →