GPR176-DT

Across TCGA pan-cancer cohorts, GPR176-DT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GPR176-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GPR176-DT RNA is repressed in tumor relative to normal tissue. In most cancer types GPR176-DT is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRC are the cancer types where GPR176-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR176-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−0.115	<.001	10	view →
THCA	Male	All	−0.051	<.001	9	view →
KIRC	Male	II,III,IV	−0.041	<.001	9	view →
HNSC	All	All	+0.025	<.001	8	view →
LUSC	Male	All	+0.068	<.001	5	view →
LUAD	Male	All	+0.048	.001	4	view →
CHOL	Male	All	+0.048	.006	4	view →
COAD	All	II,III,IV	+0.021	.010	4	view →
READ	All	III,IV	+0.070	.019	2	view →
BLCA	All	All	+0.068	.045	2	view →
ESCA	All	II,III,IV	+0.035	.019	2	view →
KIRP	Male	All	−0.028	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GPR176-DT–KICH

Open the KICH breakdown →