GPR174

Across TCGA patient cohorts, GPR174 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,138 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GPR174-associated proteins across cancer lineages are RCSD1, SASH3, and SEPTIN1. Each is linked with GPR174 in more than 9 cancer types. Because this analysis shows association rather than direction, both GPR174-to-partner and partner-to-GPR174 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPR174 versus RCSD1 in HNSC, with a Pearson correlation of 0.72.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR174→partner) and Y-score (partner→GPR174) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RCSD1 →	+0.769	+1.402	<.001	<.001	3	10
HNSC	SASH3 →	+0.605	+1.407	<.001	<.001	3	10
BRCA	SEPTIN1 →	+0.985	+1.339	<.001	<.001	3	10
HNSC	WAS →	+0.635	+1.311	<.001	<.001	3	10
HNSC	WDFY4 →	+0.655	+1.351	<.001	<.001	3	10
HNSC	WIPF1 →	+0.473	+1.278	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,138 associations by consensus.

GPR174 vs RCSD1 — HNSC

Explore this scatter interactively →