GPR174

Across TCGA pan-cancer cohorts, GPR174 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated GPR174 data layer compared with 8 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher GPR174 RNA is associated with better overall survival. In most high-consensus cancer types, elevated GPR174 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and LUAD are the cancer types where GPR174 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.433	0.242	<.001	115	view →
HNSC	DFS	Median	All	0.778	0.638	<.001	112	view →
LUAD	OS	Median	All	0.751	0.620	<.001	67	view →
LGG	DFS	Median	All	0.650	0.802	<.001	51	view →
UVM	DFS	Quartile	II,III,IV	0.345	0.691	.003	40	view →
BRCA	DFS	Tertile	All	0.963	0.926	.005	31	view →
CESC	OS	Tertile	II,III,IV	0.937	0.721	.004	30	view →
KIRP	DFS	Median	II,III,IV	0.549	0.797	.008	26	view →
SCLC	DFS	Quartile	III,IV	0.680	0.243	.002	25	view →
UCEC	DFS	Median	III,IV	0.669	0.439	.015	24	view →
KIRC	DFS	Tertile	II,III,IV	0.553	0.292	.025	14	view →
ESCA	DFS	Quartile	III,IV	0.646	0.298	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GPR174–SKCM (OS)

Open the SKCM breakdown →