GPR174

Across TCGA patient cohorts, GPR174 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR174-associated genes across cancer lineages are p70-S6K, Bim, and ACC1. Each is linked with GPR174 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR174-to-partner and partner-to-GPR174 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by GPR174-low versus GPR174-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR174→partner) and Y-score (partner→GPR174) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	p70-S6K →	+0.209	+3.000	.048	.035	3	3
LUAD	Bim →	+0.356	+3.321	.010	.010	3	2
UCEC	ACC1 →	+0.258	+2.183	.040	.033	3	2
UCEC	Annexin-1 →	+0.551	+1.926	.002	.008	3	2
UCEC	XBP1 →	-0.170	-2.209	<.001	.009	3	2
UCEC	BRD4 →	+0.268	+2.010	.004	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

p70-S6K by GPR174 expression — LUAD

Explore this box plot interactively →