GPR174

Across TCGA cell cohorts, GPR174 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,900 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR174-associated GO terms across cancer lineages are Glycosaminoglycan metabolic process, Positive regulation of autophagy, and Immunological synapse formation. Each is linked with GPR174 in more than 3 cancer types. Because this analysis shows association rather than direction, both GPR174-to-partner and partner-to-GPR174 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycosaminoglycan metabolic process grouped by GPR174-low versus GPR174-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR174→partner) and Y-score (partner→GPR174) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Glycosaminoglycan metabolic process →	-0.053	-0.923	<.001	.004	3	4
BLOOD_Leukemia	Positive regulation of autophagy →	+0.021	+1.191	<.001	<.001	3	4
BLOOD_Leukemia	Immunological synapse formation →	-0.157	-1.833	<.001	<.001	3	4
BLOOD_Leukemia	Positive regulation of RNA polymerase II transcription preinitiation complex assembly →	+0.120	+1.576	<.001	<.001	3	4
BLOOD_Leukemia	Regulation of cytoplasmic mRNA processing body assembly →	+0.110	+2.304	<.001	<.001	3	3
BLOOD_Lymphoma	Oligodendrocyte development →	-0.092	-1.366	.003	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,900 associations by consensus.

Glycosaminoglycan metabolic process by GPR174 expression — BLOOD_Lymphoma

Explore this box plot interactively →